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Targacept's TC-5214 Achieves All Primary And Secondary Outcome Measures In Phase 2b Trial As Augmentation Treatment For Major Depressive Disorder
Targacept, Inc. (NASDAQ: TRGT) today announced positive top-line results from a double blind, placebo controlled, flexible dose Phase 2b clinical trial of TC-5214 as an augmentation (add-on) treatment for major depressive disorder, or MDD, in subjects who did not respond adequately to first-line treatment with citalopram alone. The result on the primary outcome measure for the trial, mean change between treatment (TC-5214 + citalopram) and placebo (placebo + citalopram) from baseline on the Hamilton Rating Scale for Depression-17, or HAM-D, was highly statistically significant in favor of TC-5214 (p Next Steps
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President Obama Picks New York City Health Commissioner Thomas Frieden For CDC Director
President Obama on Friday appointed New York City Health Commissioner Thomas Frieden as CDC director, according to Obama administration officials, the New York Times reports. According to the Times, Frieden, an infectious disease specialist, has "cut a high and sometimes contentious profile" in his seven years as health commissioner in New York City, during which time he has advocated for a smoking ban in restaurants and bars, made HIV testing part of routine medical exams and protected a program that distributes 35 million condoms a year. According to the Times, Frieden is expected to take office next month. The Times reports that he will "inherit a host of immediate and long-term problems," including questions surrounding a vaccine for the H1N1 influenza virus, also known as swine flu, health care reform and organizational issues at CDC.The Times reports that a potential advantage for Frieden is a positive relationship with likely FDA Commissioner Margaret Hamburg, who also was New York City health commissioner. Frieden would work with Hamburg to combat the H1N1 flu virus and to re-evaluate the U.S. food safety system (Harris/Hartocollis, New York Times, 5/15).
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ACCP Position Paper On Genetic Tests Advertised Directly To The Consumer
Genetic testing services have recently begun to be advertised directly to the patient, and the results of the consumers" response can affect public health, as well as the future adoption of pharmacogenetic/genomic testing, according to a position paper from the American College of Clinical Pharmacology (ACCP) to be published in the August 2009 issue of the Journal of Clinical Pharmacology. The journal is published on behalf of the ACCP by SAGE.
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3-Day Polio, Measles Vaccination Campaign Launched In Uganda

Uganda on Saturday launched a three-day polio and measles immunization campaign, Possy Mugyenyi, the country"s immunization manager, said, UGPulse.com reports (Nyanzi, UGPulse.com, 6/5). More than 6 million children are being targeted, IRIN reports (IRIN, 6/5). Uganda"s Ministry of Health, the WHO, UNICEF and Red Cross in Uganda are supporting the campaign, which aims to vaccinate children between the ages of 47 months and nine years against measles and children younger than age five against polio. Measles kills more children in Uganda than any other "vaccine-preventable disease," AfricaNews reports (AfricaNews, 6/6). Since February, about 2,000 polio cases have been confirmed in Uganda after the country had basically eradicated the disease for more than a decade, Mugyenyi said (UGPulse.com, 6/5). "Immunizing children is a national and, indeed, a global public good that benefits everyone," Keith McKenzie, the UNICEF representative in Uganda, said. "This is not the time for complacency; this is a time to accelerate toward that good" (AfricaNews, 6/6). "To get rid of childhood diseases like polio and measles, we need to achieve 100 percent coverage," Paul Kaggwa, health ministry spokesman, said. "We are now getting many measles cases due to low immunization coverage" (IRIN, 6/5). Government Could Use Legal Efforts To Force Parents To Get Children Immunized, Health Ministry Spokesman Says Kaggwa said the government might use the "law to rein in parents" who do not get their children immunized during the campaign, Ultimate Media/UGPulse.com reports. "We are considering resorting to the law to compel parents to take their children for immunization," Kaggwa said (Ultimate Media/UGPulse.com, 6/6). He added, "We can charge parents under the Public Health Act, the Penal Code Act and the Children"s Statute. Refusing to immunize a baby infringes its right to health and at the same time exposes other children to infections" (IRIN, 6/5). After the campaign started, "[t]housands of parents" from around the country "jammed immunisation centres" and "rushed their children" to receive polio and measles vaccines, New Vision reports. Mugyenyi said, "The turn-up on day one was overwhelming," and added that there was a shortage of vaccines at some sites on the first day because of distribution issues. "We had given an equal amount of vaccines to all sub-counties. After the high turn-up in some areas, we had to redistribute," he said (New Vision, 6/7). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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