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Less Sleep Associated With High, Worsening Blood Pressure In Middle Age
Middle-aged adults who sleep fewer hours appear more likely to have high blood pressure and to experience adverse changes in blood pressure over time, according to a report in the June 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
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1st Anticancer Drug For Animals Offers Human Treatment Possibilities
AB Science, a young Paris-based biotech company, announces the pan-European commercial launch of its Masivet veterinary anticancer drug in June 2009. Masivet was approved in November 2008 by the European Medicines Agency (EMEA) for the treatment of dogs with non-resectable grade 2 or 3 mast cell tumours. Masivet"s active pharmaceutical ingredient is masitinib, a tyrosine kinase inhibitor. Masitinib, discovered and developed by AB Science, belongs to a therapeutic class of drug known as targeted therapy that is revolutionising the treatment of cancer in humans.
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Vaginal Ring Could Protect Against HIV, Researcher Says
A researcher with Weill Cornell Medical College has developed a vaginal ring that releases microbicides and could prevent HIV and unplanned pregnancies, ANI/Times of India reports. Brij Saxena -- a professor of reproductive biology and endocrinology and lead author of a recent study on the ring in the journal AIDS -- said that laboratory testing showed the device would be effective at preventing HIV infection and pregnancy by releasing several types of nonhormonal agents and microbicides. He added that if proven successful in clinical trials, the device would allow women to effectively protect themselves from HIV and avoid pregnancy. According to Saxena, the ring releases antiretroviral drugs over a period of 28 days. He noted that the device potentially could serve as an alternative method to prevent other sexually transmitted infections. Jeffrey Laurence, co-author of the study and a physician at New York Presbyterian Hospital-Weill Cornell Medical Center, said, "No one has ever conquered a viral epidemic with treatment, so prevention is the most effective option." He added, "Ideally, an HIV vaccine is the most desirable method, but that is not foreseeable in the near future. The next best thing would be something that would prevent infection and put the power in the susceptible female partner"s control. That"s the potential a device such as this can offer" (ANI/Times of India, 5/20).
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A Feasible, Simple And Convenient Model For Study Of Rectal Carcinoma

The method of building a rabbit rectal VX2 carcinoma model by injecting the cell suspension of VX2 cells into the wall of the rectum guided by X-ray fluoroscopy is feasible. The advantages of the model are ease of establishment, short growth period, and high stability. The rectal VX2 carcinoma established in this rabbit model is similar to human rectal carcinoma in aspects of pathological representation, tumor development, and metastasis. It offers an ideal major animal model for the study of rectal carcinoma, and especially profits the study of the staging of rectal carcinoma in imaging. A research article published on May 7, 2009 in the World Journal of Gastroenterology addresses this problem. The research, led by Dr. Cheng from Department of Radiology, the Tenth People"s Hospital of Shanghai Tong Ji University, is to establish a rabbit model of rectal VX2 carcinoma for a feasible, simple, and convenient method for the study of rectal carcinoma. Currently, the experimental animal models for the research of rectal carcinoma are often established using induction of chemical carcinogen, and little murid is most often used. This kind of methods requires lots of time and individual variations can be very large. Overall it is difficult to obtain consistent, single tumor which are representative of the course of rectal disease in humans, and it is adverse to perform the research of rectal carcinoma. The method of building a rabbit rectal VX2 carcinoma model by injecting the suspension of VX2 cells into the wall of the rectum guided by X-ray fluoroscopy is feasible. The advantages of the rectal VX2 carcinoma established in this rabbit model are ease of establishment, short growth period, and high stability. The model is repeatable and can be monitored dynamically using imaging provided by CT and MRI. It profits the research of rectal carcinoma, especially in the aspect of rectal carcinoma"s staging in imaging. Many studies have described the implantation of the VX2 cell strain into the muscle, kidney, lung, pleural, ossature, and mammary gland of rabbit in order to produce an in situ tumor model that mimics the human condition for research of possible treatments. The implantation technique using VX2 cells which included implanting a little lump of VX2 tumor tissue or injection of the suspension of VX2 cells directly by surgery, and injection of the suspension of VX2 cells guided by B-mode ultrasonics or CT is reliable. Both the Sixth People"s Hospital of Shanghai Jiao Tong University and the Tenth People"s Hospital of Shanghai Tong Ji University are general hospital and teaching hospital. The Department of Radiology of the Sixth People"s Hospital of Shanghai Jiao Tong University has set one study organization(Institute of Imaging Medical of Shanghai Jiao Tong University), two clinic parts(department of image and the center of neurointerventional), and five second branches(head and neck, musculoskeletal, chest, abdomen and interventional). Reference: Liang XM, Tang GY, Cheng YS, Zhou B. Evaluation of a rabbit rectal VX2 carcinoma model using computed tomography and magnetic resonance imaging. World J Gastroenterol 2009; 15(17): 2139-2144 http://www.wjgnet.com/1007-9327/15/2139.asp Correspondence to: Dr. Ying-Sheng Cheng, Department of Radiology, the Tenth People"s Hospital of Shanghai Tongji University, No. 301, Yanchang Middle Road, Shanghai 200072, China. Lin Tian World Journal of Gastroenterology


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