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University of Michigan Study Finds Women Underrepresented In Cancer Research
Women are under-represented in clinical cancer research published in high-impact journals, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center.
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Nearly 1 In 10 Kids Report Cyber Bullying
New research shines a light on the phenomenon of "cyber bullying," suggesting that nearly 1 in 10 children are bullied through electronic means such as text messages, and girls are more likely to be victims than boys are.
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Medarex Announces Primary Endpoint Achieved In MDX-1100 Anti-IP-10 Antibody Phase 2 Trial For Rheumatoid Arthritis
Medarex, Inc. (Nasdaq: MEDX) announced that the MDX-1100 Phase 2 proof-of-concept trial in patients with active rheumatoid arthritis (RA) receiving methotrexate successfully met its primary endpoint. The top-line results from the recently completed 70-patient multi-center, randomized, double-blind, placebo-controlled Phase 2 trial indicated that when compared to placebo, three times the number of patients treated with 10 mg/kg of MDX-1100 every two weeks achieved at least a 20% improvement in RA signs and symptoms at 12 weeks, the primary endpoint of the study, as measured by the American College of Rheumatology (ACR) 20 measurement of response. These results were statistically significant when compared with placebo (p=0.0024). The antibody combination with methotrexate was generally safe and well-tolerated. Full results from this Phase 2 trial are planned to be presented at a future scientific meeting.
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'Ballooning' Spiders Grounded By Infection

Money spiders infected with Rickettsia bacteria are less likely to "balloon" - that is, to use their silk as sails to catch gusts of wind and travel long distances. Researchers writing in the open access journal BMC Biology suggest that it may be in the bacteria"s interests to ground the spiders and that this reduction in dispersal could reduce gene flow and impact on reproductive isolation within the meta-population. While working at the University of East Anglia, Sara Goodacre led an international team of researchers who investigated the microbes" effect on the spiders" ballooning behavior. She said, "Because we found no reduction in fitness associated with Rickettsia infection, the reduced long-distance dispersal seems unlikely to be simply due to decreased body condition caused by illness. Rather, we believe that reducing long-distance dispersal could be an evolved adaptive modification by bacterial infections to promote their own transmission". The researchers treated the spiders with antibiotics to reduce the bacterial infection and showed that this increased their ballooning frequency. They also observed that Rickettsia-infected spiders reared in the laboratory had reduced long-distance (but not short-distance) dispersal. This parasite-induced change in a non-reproductive trait has never been shown before and, according to Goodacre, "Clearly shows that the dynamics of ecosystem services such as a spider"s pest-controlling function may be altered as a consequence of bacterial infection". Notes: Microbial modification of host long-distance dispersal capacity Sara L Goodacre, Oliver Y Martin, Dries Bonte, Linda Hutchings, Chris Woolley, Kamal Ibrahim, C.F. George Thomas and Godfrey M Hewitt BMC Biology (in press) Article All articles are available free of charge, according to BioMed Central"s open access policy. Graeme Baldwin BioMed Central


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