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New Data Shows Requip-Modutab Improves Nocturnal Symptoms In Patients With Advanced Parkinson's Disease
New data presented at the 13th International Congress of Parkinson"s Disease and Movement Disorders show that Requip-Modutab* (ropinirole prolonged release tablets) improves nocturnal symptoms experienced by patients with advanced Parkinson"s disease (PD).[i] The data showed that patients with more significant nocturnal symptoms had a greater improvement with Requip-Modutab, when used as an adjunct to levodopa (L-dopa), versus placebo. These data indicate that once-daily Requip-Modutab remains effective in treating PD symptoms over the night as well as during the day and provides benefit to those in most need. Sleep disturbances, a key element of nocturnal symptoms, are one of the most common non-motor complications of PD and can affect up to 98% of patients.[ii]
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Cardiologists' Study Shows Red Yeast Rice Cuts Cholesterol
New research from two Philadelphia-area cardiologists finds that an over-the-counter dietary supplement sold at pharmacies and health food stores may be an alternative for patients who cannot take traditional statin medications to lower cholesterol because of statin-related muscle pain. The findings of their study, "Red Yeast Rice for Dyslipidemia in Statin-Intolerant Patients," appear in the June 16, 2009 issue of Annals of Internal Medicine.
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Scientists Link Elevated Insulin To Increased Breast Cancer Risk
Elevated insulin levels in the blood appear to raise the risk of breast cancer in postmenopausal women, according to researchers at Albert Einstein College of Medicine of Yeshiva University. Their findings are published in the online version of the International Journal of Cancer.
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Cigarette Smoking Does Not Affect Everyone In Same Way

Cigarette smoking induced COPD, or chronic obstructive pulmonary disease, is a disease that results in severe breathing difficulty. According to World Health Organization (WHO) it is the fourth leading killer worldwide. However the mechanisms responsible for some smokers developing COPD and others evading the disease have not been well understood. Dr.Manuel Cosio from the McGill University Health Centre, in collaboration with Italian and Spanish scientists, reports in the New England Journal of Medicine that an autoimmune mechanism, compounded by genetic predisposition in COPD, would explain the progression of the disease in some smokers and the evasion in others. COPD has a family connection and next of kin of patients with COPD have a much higher chance of developing the disease, a characteristic of autoimmune diseases. Although smoking is the primary risk factor for COPD in the western world, open fire pollutant cooking and heating fuels in the home is an important risk factor for the development of COPD in women in developing nations. "Smoke can play an important role in autoimmune diseases such as COPD, and other diseases like rheumatoid arthritis, because it accentuates genetic predispositions to the disease," warns Dr. Cosio. Yet contrary to previous scientific beliefs, COPD does not progress in the same way in all smokers. The authors describe three steps in the potential progression to COPD in smokers: "COPD does not go from stage one, two and three in all people," Dr. Cosio says. "Depending on their personal balance between immune response and immune control some people would stop at stage one, others at stage two, and some will progress to stage three, full autoimmunity and lung destruction." "Hopefully investigators will now see the disease in a totally different way," Dr Cosio stresses. "Our hope is that our research will open the door for a different investigation on COPD, where scientists learn more about the immunological processes and how these processes could be controlled and modulated to eventually provide the right treatment." Notes: Dr Manuel Cosio: Dr Manuel Cosio is Professor of respiratory medicine at the McGill University Health Centre (MUHC) and an investigator in "Respiratory health" at the Meakins Christie laboratories of the Research institute of the MUHC. Funding: This study was supported by the Lloyd-Carr Harris Foundation, the Italian Ministry of University and Research and CIBERES (Centro de investigaci̚n biom̩dica en red sobre enfermedades respiratorias). Partners: This article was authored by Dr.Manuel G. Cosio of the McGill University Health Centre (Canada), Dr.Marina Saetta of the University of Padua, (Italy) and Dr.Alvar Agusti of the Hospital Universitario Son Dureta, (Spain). Isabelle Kling McGill University Health Centre


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