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Studies Examine Morning Sickness Drug, Progesterone Use To Prevent Premature Birth
The following summarizes news coverage on two pregnancy-related studies. ~ Morning sickness: The commonly prescribed heartburn drug metoclopramide -- sold generically and under the brand-names Reglan, Octamide and Maxolon -- can be used to treat morning sickness without harming the health of the fetus, according to a study published on Thursday in the New England Journal of Medicine, Time reports. The drug, which also has anti-nausea properties, is not FDA-approved for use in pregnant women in the U.S., though it is commonly prescribed in European and other countries to treat morning sickness (Park, Time, 6/10). According to the Los Angeles Times, U.S. physicians occasionally prescribe metoclopramide to treat severe morning sickness cases. The new study found that there were no statistically significant differences between infants born to women who took metoclopramide and those who did not. Researchers said that the findings "provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy." The study involved 81,703 births among women enrolled in Israel"s largest health HMO, including 33,458 who used the drug (Maugh, Los Angeles Times, 6/11). Jennifer Niebyl, a professor of obstetrics and gynecology at the University of Iowa, said, "There are very few drugs approved for use in the first trimester of pregnancy. But this study could lead to metoclopramide getting approved to treat morning sickness because this is good data with big numbers" (Time, 6/10).~ Progesterone: The hormone progesterone was not effective at preventing premature births among women pregnant with twins, despite evidence suggesting its effectiveness at preventing premature births in single pregnancies, according to a University of Edinburgh study published in the journal Lancet, Reuters reports. Multiple pregnancies have a larger health risk for women and significantly increase the likelihood of miscarriage, premature birth and long-term health problems. The study involved 500 women who took either progesterone or a placebo daily for 10 weeks. Although previous studies have shown that progesterone might prevent premature birth in certain high-risk pregnancies, the new findings show the treatment did not reduce the likelihood of premature delivery or a fetus dying in utero in twin pregnancies. Twenty-five percent of women delivered or had a fetus die before 34 weeks in the progesterone group, compared with 20% in the placebo group (Kahn, Reuters, 6/10).
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New Software To Improve Clinical Trial Performance
TranSenda International, LLC announced today that it is developing a new solution, Cortex, designed to improve an organization"s ability to manage a clinical trial"s performance. Based upon patent-pending ClinBUS® data interchange technology already in use in TranSenda"s Office-Smart solutions, Cortex will enable organizations to leverage the power of access to centralized operational data from all applications used across all clinical studies. For years the industry has struggled with an increasingly fragmented environment of disconnected clinical applications, sites and partners. TranSenda"s Cortex, with its proven ClinBUS technology, represents a breakthrough in managing and controlling studies within a common environment-independent of study data formats and clinical trial applications.
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The Spelling Mistake In The Genetic Code That Causes A Type Of Ovarian Cancer
Eureka! Vancouver scientists from the Ovarian Cancer Research (OvCaRe) Program at BC Cancer Agency and Vancouver Coastal Health Research Institute have discovered that there appears to be a single spelling mistake in the genetic code of granulosa cell tumours, a rare and often untreatable form of ovarian cancer. This means that out of the three billion nucleotide pairs that make up the genetic code of the tumour, one - the same one in every tumour sample - is incorrect. The discovery, published online June 10th in the New England Journal of Medicine, marks the beginning of a new era of cancer genomics, where the complete genetic sequence of cancers can be unravelled and the mutations that cause them exposed. For women with granulosa cell tumours it represents the first specific diagnostic tool and clear path to develop much needed treatments for this cancer.
Mental Health

Economic Crisis Heightens Financial Fallout For Bereaved

One in five people fall below the official poverty line following the death of their partner. "Hence the recent fall in the value of annuities, savings and investments means an even wider group of older people could face financial difficulties when their partner dies, whether these difficulties are short-lived or longer lasting," says researcher Anne Corden of the Social Policy Research Unit, University of York People, whose partners had been in paid work, reported the largest income falls, mainly affecting those under pension age. Women with or without children were more at risk of financial decline than men and two in five women pensioners were in poverty immediately after bereavement.. While some of these experiences of poverty were short-lived, bereaved women were more likely to experience poverty lasting up to three years after the death. The number of women feeling financially worse off doubled from 24 per cent to 48 per cent. Comparable figures for men were 19 and 30 per cent respectively. Based on its exploration of a wide range of economic, administrative, emotional, and psychological issues following the death of a partner, the study highlights the need for: Better awareness of financial issues * Findings highlighted the financial consequences of the failure to make a will and the mistaken belief that "common law marriage" provides legal rights. * "Many people still put off thinking about their will or their finances until they are older and by then, for some, it is too late," Corden points out. * The study highlights the importance of financial awareness within the general population. * The need to make financial preparations and decisions as a couple during earlier stages of their life together. Easing adjustment to loss * Grief has economic elements which impact on the grieving process and adjustment to loss. Managing money, and taking on new economic roles was hard for some bereaved people. * The study suggests that raising financial awareness should include planning and preparation for death. * Government, employers and unions have opportunities to provide information at various key points during a person"s life. Reducing administrative and regulatory burdens * Researchers found that the administrative requirements related to financial transitions caused a considerable practical and emotional burden. * Most people had to deal with diverse administrative and regulatory bodies. The volume of work required, delays, errors and problems in communication were widely experienced as an overwhelming burden. * Researchers highlight the need of processes to help people find information they need quicker, staff with skills for dealing with people in grief, and data sharing to reduce documentation required, would increase business efficiency as well as trust and compliance among service users. Counselling support for "economic components" of grief * Supporting bereaved people who want to share feelings about their financial situation and new economic roles may ease adjustment to their loss. * Findings suggest that while it is not the role of bereavement counselling services to provide expertise in all the administrative and financial aspects of bereavement, they would benefit from greater awareness of the emotional impact of changed financial circumstances on the bereaved person. Financial support for the bereaved * Immediate financial demands facing bereaved people included paying for the funeral and housing costs including changes in home ownership and tenancy. * After a death, information and advice about benefits, pensions and tax, as well as support in accessing financial services help people avoid financial hardship. * Researchers suggest that when policymakers review financial support for bereaved people, there should be thorough examination of entitlement, take-up and impact of bereavement benefits and social fund funeral expenses payments, and people"s perceptions of these payments. Researchers conclude that some financial difficulties following death of a partner can be prevented; others can be avoided. Policymaking must address the immediate circumstances of people experiencing bereavement. In the long term, enabling people to sustain paid employment throughout their working lives, occupational and private pensions, will help ensure an acceptable standard of living in retirement and protect people whose partner has died from financial hardship and economic decline. Press Office Economic & Social Research Council


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