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MicroRNAs Grease The Cell's Circadian Clockwork
Most of our cells possess an internal clock, a group of genes displaying a cyclic expression pattern that reaches a peak once a day. A large number of circadian genes are expressed by organs such as the liver, whose activity needs to be precisely regulated over the course of the day. A team of researchers of the National Centre of Competence in Research Frontiers in Genetics, based at the University of Geneva, Switzerland, reveals that an important regulator of this molecular oscillator is a specific microRNA. The latter belongs to a class of small RNA molecules that regulate the production of proteins in our cells. Thus far, little was known about their function within the circadian clockwork. The study by Ueli Schibler"s team, published in the 1st June edition of Genes & Development, fills in this important gap.
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New Heart Disease Risk Score Should Be Recommended In The UK, Say Experts
A new score for predicting a person"s risk of heart disease performs better than the existing test and should be recommended for use in the United Kingdom by the National Institute for Health and Clinical Excellence (NICE), say researchers in a paper published on bmj.com.
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CytRx Drug Candidate INNO-206 Results In Ovarian Tumor Shrinkage In Animal Trials
CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, announced that results demonstrating that its cancer drug candidate INNO-206 caused statistically significant tumor shrinkage in an animal model of ovarian cancer have been accepted for publication in the peer-reviewed journal Investigational New Drugs. The manuscript based on this animal trial, "INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model," was made available ahead of journal printing in electronic format in the January 8, 2009 on-line issue of Investigational New Drugs.
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FDA Seeks Public Input On Transparency

The U.S. Food and Drug Administration will host a daylong meeting on June 24, 2009. During this meeting, the FDA will seek recommendations on how to make information on FDA activities and decision-making useful, understandable, and more accessible to the public. The meeting is scheduled for 8 a.m. to 5 p.m. EDT at the National Transportation Safety Board Conference Center, 429 L"Enfant Plaza, S.W., Washington, D.C., 20594. Please note there is no wireless service within the NTSB Conference Center. If you have questions, please e-mail them to Transparency.Meeting@fda.hhs.gov. Those who cannot attend the meeting can view the event via live Webcast at: http://www.fda.gov/transwebcast_june09. After the meeting, the Webcast will be available for viewing at the same link. For more information: June 3, 2009 Federal Register Notice FDA"s Transparency Task Force FDA"s Transparency Blog U.S. Food and Drug Administration


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