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Targacept's TC-5214 Achieves All Primary And Secondary Outcome Measures In Phase 2b Trial As Augmentation Treatment For Major Depressive Disorder
Targacept, Inc. (NASDAQ: TRGT) today announced positive top-line results from a double blind, placebo controlled, flexible dose Phase 2b clinical trial of TC-5214 as an augmentation (add-on) treatment for major depressive disorder, or MDD, in subjects who did not respond adequately to first-line treatment with citalopram alone. The result on the primary outcome measure for the trial, mean change between treatment (TC-5214 + citalopram) and placebo (placebo + citalopram) from baseline on the Hamilton Rating Scale for Depression-17, or HAM-D, was highly statistically significant in favor of TC-5214 (p Next Steps
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Injection Reverses Heart-Attack Damage
Injured heart tissue normally can"t regrow, but researchers at Children"s Hospital Boston have now laid the groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects. In the July 24 issue of Cell, they show that a growth factor called neuregulin1 (NRG1), which is involved in the initial development of the heart and nervous system, can spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a heart attack.
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'Shock And Kill' Research Gives New Hope For HIV 1 Eradication
Latent HIV genes can be "smoked out" of human cells. The so-called "shock and kill" technique, described in a preclinical study in BioMed Central"s open access journal Retrovirology, might represent a new milestone along the way to the discovery of a cure for HIV/AIDS.
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Issue Brief Examines Disparities In Unmet Dental Care Needs Among Children

"Trends in Child Health 1997-2006: Assessing Racial/Ethnic Disparities in Unmet Dental Care Needs," Joint Center for Political and Economic Studies: The issue brief examines disparities in the reporting of unmet dental care needs because of cost over the past 12 months among black, Hispanic and white children younger than age 18. The brief compares the unmet dental care needs among the racial/ethnic groups of children overall and among children of various racial/ethnic groups in families with similar sociodemographic characteristics, such as family type, poverty status and health insurance coverage. Hispanic children are the most likely to have dental care needs that are unmet because of cost, according to the brief. In addition, the brief analyzes several indicators of child health -- including low birthweight, health status, unmet dental care needs, ADHD/ADD diagnosis and asthma diagnosis -- to provide additional details of disparities in child health (Joint Center for Political and Economic Studies, May 2009). Reprinted with kind permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation. © 2009 Advisory Board Company and Kaiser Family Foundation. All rights reserved.


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