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Philippines Health Secretary Warns Of Impending Dengue Threat
With the start of the rainy season, Francisco Duque III, health secretary in the Philippines, on Tuesday emphasized a continued government commitment to controlling and preventing dengue - a disease for which there is currently no vaccine or specific drug, the Manila Times reports.
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PolyMedix Receives United States Patent For Angiogenesis Inhibitor Compounds
PolyMedix, Inc. (OTCBB: PYMX), an emerging biotechnology company developing acute care products for infectious diseases and acute cardiovascular disorders, announced that the United States Patent and Trademark Office issued a patent assigned to PolyMedix relating to angiogenesis inhibitors. The patent, number 7,553,876, entitled "Polycationic Compounds and Uses Thereof," relates to therapeutic uses of PolyMedix compounds for inhibiting angiogenesis.
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Those With Darker Skin Might Be More Susceptible To Nicotine Addiction, Study Finds
Blacks and others with darker skin might be at greater risk for tobacco addiction than whites and those with lighter skin because the greater the amount of melanin, the coloring pigment in skin, the more nicotine appears to be stored, according to preliminary findings published in the journal Pharmacology, Biochemistry and Behavior, the New York Times reports. For the study, lead researcher Gary King, a professor of biobehavioral health at Pennsylvania State University, looked at 150 black smokers and measured their levels of melanin and cotinine, a byproduct of nicotine. They also surveyed the participants to determine the level of their smoking habit. Those with the most melanin were found to smoke the most and have the most cotinine in their system. They also had the highest level of dependence on tobacco. The findings might indicate why some people are more affected by nicotine than others, according to the study (Nagourney, New York Times, 5/19).
Public Health

New Study Shows That Next Generation FlexPen(R) Has A Significantly Lower Injection Force Than SoloStar(R) And KwikPen(R)

New data published this week in Expert Opinion Pharmacotherapy has revealed that Next Generation FlexPen®, Novo Nordisk"s prefilled insulin delivery device, has a significantly lower injection force than two other devices, SoloStar® and KwikPen®.(1,2,3) Previous studies show that people with diabetes prefer a lower injection force.(4,5) The study revealed that the injection (dose) force of Next Generation FlexPen® was 12-25% lower than SoloStar® and 35-41% lower than KwikPen®.(1) In addition to the reduced injection force, this study and others have shown that Next Generation FlexPen® has advantages over SoloStar® and KwikPen® in providing improved accuracy.(1,6,7) "Patients with diabetes generally prefer an insulin device with a lower injection force because it provides significantly less discomfort when injecting, especially for patients with impaired manual dexterity," said Professor Andreas PfÃøtzner, Institute for Clinical Research and Development, Mainz, Germany. "It is vitally important for the sake of compliance and individual satisfaction that patients with diabetes are comfortable with their insulin device as it is something they have to use on a daily basis." Next Generation FlexPen® has been available in some countries from late 2008 and is continuing to be launched in countries around the world. It has built upon the high standards set by FlexPen®. New features include 30% less force when injecting, coloured cartridge holders, labels and packaging to aid insulin type identification for patients and an innovative simple and easy needle attachment with a "Just twist" mechanism which allows the NovoTwist™ needle to be attached (to be launched from June 2009).(5) This makes the device the first pen to be designed for use with a new generation of needles, which have a patented state-of-the-art attachment interface. These features provide improved convenience and ease of use for people with diabetes.(4,5) The study compared the dose forces of Next Generation FlexPen®, SoloStar® and KwikPen® by injecting 20U of insulin using two different gauge needles (NovoFine® 32G and BD Micro-fine™ 31G). Pens of each type were tested at injection speeds of 3.3, 5.0 and 8.3mm/sec. At all three injection speeds and with both needles, Next Generation FlexPen® had a significantly lower average injection force than either SoloStar® or KwikPen®, whilst KwikPen® had the highest mean injection force. Furthermore, the injection force with all three pens was lower when the NovoFine® 32G needle was used as opposed to the BD Micro-fine™ 31G. About Next Generation FlexPen® FlexPen® is the world"s most widely used prefilled insulin pen, trusted daily by more than three million people worldwide.(8,9) Next Generation FlexPen® represents the latest advance in prefilled insulin pens from Novo Nordisk, designed to be simple and convenient to use, and helping to reduce the burden of living with diabetes. Next Generation FlexPen® is a result of more than 25 years of research and development of insulin delivery systems undertaken since Novo Nordisk invented the insulin pen. Compared to other insulin delivery devices that have to be manually loaded with insulin cartridges, prefilled pens are ready to use, eliminating the step of loading insulin into the delivery device. Next Generation FlexPen® features a single-step dose-setting mechanism, portability and a discreet "non-medical" appearance. With Next Generation FlexPen® it is not possible to set a dose larger than that remaining in the pen. It permits dose corrections without loss of insulin, and provides doses in one-unit increments up to 60 units per injection (each pen contains 300 units in total). The dose scale on Next Generation FlexPen® automatically returns to zero after injection to allow visual confirmation of dose delivery. References 1) Asakura T et al. Evaluation of injection force of three insulin delivery pens. Expert Opin Pharmcother. DOI 10.1517/14656560903018929. Posted online on 26 May 2009: http://www.informapharmascience.com/toc/eop/0/0 2) SoloStar®, a prefilled injection device, is a registered trademark of Sanofi-Aventis. 3) KwikPen®, a prefilled injection device, is a registered trademark of Humalog. 4) Sommavilla B et al. Safety, simplicity and convenience of a modified prefilled insulin pen. Expert Opin Pharmacother 2008; 9(13): 2223-32. 5) PfÃøtzner A et al. Prefilled insulin device with reduced injection force: patient perception and accuracy. Curr Med Res Opin 2008; 24(9): 2545-2549. 6) Rissler J et al. Evaluation of the injection force dynamics of a modified prefilled insulin pen. Expert Opin. Pharmacother 2008; 9(13): 2217-2222. 7) Weise A et al. Comparison of the dose accuracy of prefilled insulin pens.J Diabetes Sci Tech 2009; 3(1): 149-53. 8) Estimated number of patients using FlexPen®, based on worldwide sales in number of packs sold, IMS worldwide data Q3"08 and Daily Defined Dosage (DDD) for insulin as issued by WHO. 9) Reimer T et al. Instruction time, Intuitiveness and Patient Acceptance of a Prefilled and a Reusable Insulin Delivery Device - The NovoMix® 30 FlexPen® and the HumaPen® Luxura™. Clin. Ther. 2008; 30(12):2252-62. Novo Nordisk


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