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Mixed Neurodegenerative Disorders Are Emerging From The Shadows
Many cases of age-related neurodegenerative disease fall into the gray zone between big, defined diseases - Alzheimer"s or Parkinson"s, for example. Their diagnostic accuracy is low, researchers agree. That"s a problem, because mixed disease is not only common, but also quite different in its course from pathologically "pure" disease. (Mixed disease is often worse.) But there"s also excitement and opportunity. The large overlap between established neurodegenerative diseases is ripe for scientific exploration, and recent advances at the genetic, clinico-pathologic, and molecular levels have turned it into a dynamic area of research. In particular, diseases such as Dementia with Lewy bodies and frontotemporal dementias are drawing intense interest as biomarker development branches out beyond Amyloid beta and tau, holding out a future where molecular-based diagnoses can define the pathogenic proteins that together drive a given person"s individual disease.
News of the day
Those With Darker Skin Might Be More Susceptible To Nicotine Addiction, Study Finds
Blacks and others with darker skin might be at greater risk for tobacco addiction than whites and those with lighter skin because the greater the amount of melanin, the coloring pigment in skin, the more nicotine appears to be stored, according to preliminary findings published in the journal Pharmacology, Biochemistry and Behavior, the New York Times reports. For the study, lead researcher Gary King, a professor of biobehavioral health at Pennsylvania State University, looked at 150 black smokers and measured their levels of melanin and cotinine, a byproduct of nicotine. They also surveyed the participants to determine the level of their smoking habit. Those with the most melanin were found to smoke the most and have the most cotinine in their system. They also had the highest level of dependence on tobacco. The findings might indicate why some people are more affected by nicotine than others, according to the study (Nagourney, New York Times, 5/19).
Diagnostics

New Treatment Method Reduces Pain And Increases Mobility In Patients With Vertebral Compression Fractures

Vesselplasty, a new minimally invasive procedure, increases mobility and reduces pain and the need for pain killers in patients with vertebral compression fractures (VCFs), according to a study performed at the Hospital Universitario Doctor Peset, Valencia, Spain. Vesselplasty is a new alternative to vertebroplasty and kyphoplasty-two conventional VCF treatment methods. Vesselplasty solves the problem of leakage of cement out of the vertebral body which can happen during both vertebroplasty and kyphoplasty," said Lucia Flors, MD, lead author of the study. The study included 29 patients with VCFs who underwent vesselplasty. "After the procedure, all patients had improvements in their pain scores; 93% of patients had improvements in mobility; and 62% of patients had a decreased need for pain killers," said Dr. Flors. There was no evidence of clinical complications following the procedure. "Vertebral compression fractures often cause severe, disabling pain and progressive deformities of the spine in osteoporotic patients," she said. "Vesselplasty is a safe alternative in the treatment of VCFs. It is an image-guided procedure that only requires conscious sedations and local anesthesia. Most patients refer improvement in their level of pain immediately following the procedure," said Dr. Flors. This study appears in the July issue of the American Journal of Roentgenology. Click here for abstract. The American Roentgen Ray Society


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