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New One-Year Data From REMICADE(R) SONIC Trial Show Sustained Efficacy Compared With Azathioprine In Treatment Of Crohn's Disease
New long-term findings from the Phase 3b study of patients with moderately to severely active Crohn"s disease having inadequate response to conventional therapies, but naive to immunomodulators and biologic therapy, were presented at Digestive Disease Week today. Data from the SONIC study showed that a greater proportion of patients receiving REMICADE (infliximab) maintained steroid-free remission at one year, compared with patients receiving azathioprine alone.
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States Undergo A Variety Of Health Care Policy Developments
Connecticut: The Associated Press/Hartford Courant reports, "Gov. M. Jodi Rell has vetoed two health insurance bills he said were "well-intentioned" but "would cost the state billions of dollars before any economic recovery is complete." Unions and health care advocates had pressured the Republican governor to sign the measures. "[O]ne of the billsò€¦ opens the state"s health insurance plan to municipalities, small businesses and nonprofit agencies. The second bill creates a new public authority to develop a plan to extend coverage to the state"s uninsured." It"s not yet clear if Democrats, who have a veto-proof majority in the General Assembly, will try to override Rell"s action (7/8).
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Millions Of U.S. Children Low In Vitamin D
Seven out of ten U.S. children have low levels of vitamin D, raising their risk of bone and heart disease, according to a study by researchers at Albert Einstein College of Medicine of Yeshiva University. The striking findings suggest that vitamin D deficiency could place millions of children at risk for high blood pressure and other risk factors for heart disease.
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No More Test Tubes On Four Feet? EPA Moves Toward Animal-free Toxicity Tests

The U.S. Environmental Protection Agency (EPA) plans to switch to a new generation of animal-free tests for predicting the toxicity of chemicals to humans, according to an article scheduled for the June 22 issue of Chemical & Engineering News, ACS" weekly newsmagazine. C&EN associate editor Britt Erickson points out that there are more than 80,000 chemicals on the market, with about 700 more added each year. Over the next ten years, EPA plans to increasingly rely on so-called toxicity-based pathways to evaluate these substances. This approach involves using human cell cultures to screen newly marketed chemicals for adverse effects. The new tests will produce results in a fraction of the time now required with animal studies. But the switch won"t be easy, the C&EN article notes. Some experts question the validity of these next-generation tests. Meanwhile, new technologies for predicting toxicity may emerge and complement conventional animal tests, according to the article. American Chemical Society


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