Popular Articles

Immunotherapy Against Tau Tangles In Alzheimer's Mouse Models
New insights into how a Phase III Alzheimer"s drug might work were among the advances in potential therapies targeting two abnormal brain proteins - beta amyloid and phosphorylated tau - at ICAD.
pharmacy online
GOP Senators Signal They Will Not Block Sotomayor; Full Senate Vote Expected By Aug. 7
Senate Republicans on Thursday said that they do not plan to block a vote on Supreme Court nominee Sonia Sotomayor, the Washington Post reports. Senate Judiciary Committee ranking member Jeff Sessions (R-Ala.) told Sotomayor that he would not support any effort to filibuster her nomination, meaning that she would need a simple majority of 50 votes to be confirmed. Because Democrats hold 60 votes in the Senate, Sessions" comments effectively end "any possible suspense over her fate," according to the Post (Kane et al., Washington Post, 7/17). Sessions said, "I will not support and I don"t think any member of this side will support a filibuster or any attempt to block a vote on your nomination," adding, "I look forward to you getting that vote before we recess in August." According to CQ Politics, Sessions" statement that Republicans will not filibuster "is bound to rile conservative activists," who have urged GOP senators to delay the vote to allow more time to build opposition.Sen. Lindsey Graham (R-S.C.) also signaled that he would vote for Sotomayor"s confirmation (Perine, CQ Politics, 7/16). He said, "We"ll see what your future holds, but I think it"s going to be pretty bright" (Bendavid, "Washington Wire," Wall Street Journal, 7/16). Sen. James Inhofe (R-Okla.) said that although he will not support Sotomayor"s confirmation, he will not filibuster the vote (Rushing, The Hill, 7/16). Sen. Tom Coburn (R-Okla.) told Sotomayor, "Thank you for giving us such a cordial response, and I am mightily impressed" (Washington Post, 7/17).Voting Timeline UnclearSenate Judiciary Committee Chair Patrick Leahy (D-Vt.) said he would schedule a committee vote on the nomination for July 21. It remains unclear whether committee Republicans will delay the vote until July 28, as they are permitted to do under committee rules. Sessions called the July 21 vote "unrealistic," adding that there "will be a number of questions submitted to the nominee that take some time" (CQ Politics, 7/16). A party-line vote on the nomination does not seem likely, as a number of committee Republicans have praised Sotomayor and signaled that they will vote to confirm her, the AP/Boston Globe reports (Holland, AP/Boston Globe, 7/17). The committee"s vote serves as a recommendation to the full Senate, which likely will hold its final roll-call vote on the nomination by Aug. 7 (Washington Post, 7/17). Senate Majority Leader Harry Reid (D-Nev.) on Thursday said he wants a floor vote on Sotomayor "as quickly as possible" (Brady, Roll Call, 7/16).During the hearing on Thursday, Sotomayor reiterated that she would consider each case individually and declined to state her specific views on abortion rights. In response to Coburn, she said, "Would you want a ... nominee who came in here and said, "I agree with you. This is unconstitutional," before I had a case before me?" She added, "I don"t know that that"s a justice that I can be" (Kiely/Biskupic, USA Today, 7/17). According to the New York Times, "Some observers thought they detected her tipping her hand on abortion rights when she said Supreme Court precedents required abortion restrictions to make exceptions for a woman"s health" (Savage, New York Times, 7/17).
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Removal Of Tonsils And Adenoids Associated With Ongoing Benefits For Children With Breathing Problems During Sleep
Two and a half years after children with sleep-related breathing disorders had surgery to remove their tonsils and adenoids (glands in the back of the throat), they appear to sleep better than they did before the procedure but not as well as they did six months after, according to a report in the July issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals. Initial improvements in their behavior were maintained except when measured by an index of attention-deficit/hyperactivity disorder (ADHD) symptoms.
Mental Health

Prize Winning Research Could Bring Relief To 3.5 Million Denture Stomatitis (Oral Thrush) Sufferers

A research project, which has the potential to bring relief to the estimated 3.5 million UK sufferers of oral thrush, has won the ÷£25,000 Armourers & Brasiers Venture Prize. This will allow the project to proceed to clinical evaluation. According to the most recent adult dental survey, 28 percent of the UK population wears dentures and a quarter of these are likely to develop denture stomatitis or fungal induced stomatitis (mainly Candida albicans), commonly known as oral thrush. This is a significant problem for denture wearers and is seemingly on the increase. The Armourers & Brasiers Venture Prize, which is awarded annually in the form of an investment, enables the winner to engage in the early commercialisation of promising research and has been won by a team of scientists from the University of Liverpool. This team is led by senior lecturer and material scientist, Dr Rachel Williams, and senior lecturer in oral surgery, Dr Luke Dawson. The project"s idea is based on a cost effective nanoparticle silica coating which inhibits the adhesion and proliferation of cells and micro-organisms. Laboratory tests show that the nanoparticulate silica coating can inhibit the build up of virulent oral thrush (Candida albicans). Using Proof of Concept (POC) funds awarded by the University technology transfer company, Ulive, the team has developed a transparent solution containing the nanoparticles with adhesive patches on each particle which promote attachment to the denture. This solution can be used by denture wearers as part of their normal cleaning procedure and provides a renewable, tasteless nanoparticulate coating on the dentures which will prevent oral thrush infections. "Our approach will reduce the need for sufferers of oral thrush to be treated by drug therapy. This is important as these drugs cannot be used in all patients", said Dr Williams. "Our product aims to prevent the occurrence of oral thrush and maintain a healthy mouth via continual renewal of the nanoparticle coating." "Having proved the principle in the laboratory using the Ulive POC funding we now need to assess this product in a clinical setting," continued Dr Williams. "The prize win will go towards carrying out clinical trials and evaluation in key patient groups." "This product is a very worthy winner," explained Professor Bill Bonfield chairman of the Armourers & Brasiers Venture Prize judging panel. "Our aim is to stimulate and encourage British based materials science development and Dr Williams and her team is, by exploiting materials technology that inhibits cell-surface interactions, using a science that will have a highly significant bearing on the development of materials and surfaces in healthcare." Alongside Professor Bonfield on the judging panel were Cambridge based material scientist Professor Colin Humphreys, representatives from First Ventures which invests and advises high potential technology companies and Members of the Armourers & Brasiers Company. "We see significant potential for this product as a regular denture cleaning product," said Dr Williams. "Worldwide market opportunities are significant especially in the developed world due to an aging population leading to an increasing number of denture wearers." The Liverpool University team comprises Dr Rachel Williams (lead; School of Clinical Sciences), Dr Luke Dawson (School of Dental Sciences), colloid scientist Dr. Mike Garvey (Department of Physics), microbiologist Dr. Heather Allison (School of Biological Sciences) and business manager Dr. Gillian Murray (Ulive Enterprises) The Armourers & Brasiers Company


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