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Insights Into Failed HIV-1 Vaccine Trial: Study
Following the disbandment of the STEP trial to test the efficacy of the Merck HIV-1 vaccine candidate in 2007, the leading explanation for why the vaccine was ineffective - and may have even increased susceptibility to acquiring the virus - centered on the hypothesis that high levels of baseline Ad5-specific neutralizing antibodies may have increased HIV-1 acquisition among the study subjects who received the vaccine by increasing Ad5-specific CD4+ T-cells that were susceptible to HIV-1 infection.
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New Study Indicates That Parents' Influence On Children's Eating Habits Is Small
The popular belief that healthy eating starts at home and that parents" dietary choices help children establish their nutritional beliefs and behaviors may need rethinking, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health. An examination of dietary intakes and patterns among U.S. families found that the resemblance between children"s and their parents" eating habits is weak. The results are published in the May 25, 2009, issue of Social Science and Medicine.
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An Examination Of California's Proposed Budget Cuts
The New York Times reports on a series of deep budget cuts to help California, which is some $24 billion in the red, deal with its" ongoing financial woes.
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Risks Of Delaying Anterior Cruciate Ligament Reconstruction In Young Athletes May Be Too High, Study Shows

More and more children are participating and getting hurt playing sports each year. A new study presented at the American Orthopaedic Society for Sports Medicine"s (AOSSM) Annual Meeting in Keystone, Colorado, (July 9-12) details the benefits and risks of repairing a torn anterior cruciate ligament (ACL) in young athletes under the age of 14. "The risk of inducing a growth disturbance with early reconstruction of a torn ACL must be balanced against the risk of further knee damage by delaying treatment until closer to skeletal maturity. Our study measured the independent risk factors for and relative risk of meniscal and chondral injuries in pediatric ACL patients," said author, Theodore J. Ganley, MD, Director of the Sports Medicine and Performance Center for The Children"s Hospital of Pennsylvania and the University of Pennsylvania School of Medicine. Researchers analyzed the records of 69 patients, 14 years of age and younger who had undergone ACL reconstruction between 1991 and 2005. Data collected included demographics, relevant history (mechanism and side of injury, time from injury to surgery, one or more episodes of instability with activity, use of brace and return to sports), earliest MRI findings and physical exam findings. Operative reports and intra-operative images were also used to classify meniscal and articular cartilage pathology. All of the patients were counseled as to the benefits and risks of delaying ACL reconstruction and advised to avoid any at-risk activities along with participating in physical therapy prior to their reconstruction. If the decision was made to delay treatment, patients were instructed to wear a custom ACL brace. All patients who underwent the surgery utilized a soft tissue graft with anatomically placed tunnels and fixation devices that did not cross the growth plate. Patients were also followed for a minimum of one-year post-operatively with no growth disturbances being noted. "In our study, the largest of skeletally immature patients to evaluate independent risk factors, a delay in treatment of more than 12 weeks had about a four-fold increase in irreparable medial meniscus tears, an 11-fold increase in lateral compartment chondral injuries and a three-fold increase in patellotrochlear injuries. Issues with instability in the knee were also increased significantly. Our results highlight and help quantify the risk associated with delaying ACL reconstruction in young athletes and the need for continued injury prevention efforts," said Ganley. The American Orthopaedic Society for Sports Medicine


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