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Medarex Announces Primary Endpoint Achieved In MDX-1100 Anti-IP-10 Antibody Phase 2 Trial For Rheumatoid Arthritis
Medarex, Inc. (Nasdaq: MEDX) announced that the MDX-1100 Phase 2 proof-of-concept trial in patients with active rheumatoid arthritis (RA) receiving methotrexate successfully met its primary endpoint. The top-line results from the recently completed 70-patient multi-center, randomized, double-blind, placebo-controlled Phase 2 trial indicated that when compared to placebo, three times the number of patients treated with 10 mg/kg of MDX-1100 every two weeks achieved at least a 20% improvement in RA signs and symptoms at 12 weeks, the primary endpoint of the study, as measured by the American College of Rheumatology (ACR) 20 measurement of response. These results were statistically significant when compared with placebo (p=0.0024). The antibody combination with methotrexate was generally safe and well-tolerated. Full results from this Phase 2 trial are planned to be presented at a future scientific meeting.
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Lilly Receives Fourth FDA Approval For ALIMTA(R) - First Chemotherapy Approved As Maintenance Therapy For Nonsquamous Non-Small Cell Lung Cancer
Eli Lilly and Company (NYSE: LLY) announced it received a fourth approval from the U.S. Food and Drug Administration (FDA) for ALIMTA® (pemetrexed for injection). The latest approval is for ALIMTA as a maintenance therapy for locally advanced or metastatic non-small cell lung cancer (NSCLC), specifically for patients with a nonsquamous histology whose disease has not progressed after four cycles of platinum-based first-line chemotherapy. ALIMTA is not indicated for treatment of patients with squamous cell non-small cell lung cancer.
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A Step Closer To Drugs Against Winter Vomiting Disease
The virus that causes winter vomiting disease invades cells by attaching to particular sugar molecules on the surface of the cells. This is the conclusion of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden. This result may be an important step in the development of a drug against the regular hospital-based epidemics caused by the virus.
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The Dangers Of 'Extreme' College Drinking And A Sensation-Seeking Disposition

Drinking on college campuses in the United States is a pervasive problem, leading to numerous problems. One study estimated that more than 500,000 college students suffered alcohol-related injuries in 2001. This study examined the "dose-response" effect of quantities and frequencies, finding that heavy drinkers with a sensation-seeking disposition had the greatest risk of alcohol-related injuries. Results will be published in the September issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View. "In the United States, most - as in 70 percent - of college students have consumed alcohol in the past 30 days, and 40 percent of students have engaged in heavy drinking in the past two weeks," said Marlon P. Mundt, assistant scientist in the department of Family Medicine at the University of Wisconsin-Madison and corresponding author for the study. "More than 1,700 U.S. college students aged 18-24 died from alcohol-related injuries in 2001," he added. "Approximately 2.8 million U.S. college students drove under the influence of alcohol in the past 12 months, and 600,000 U.S. college students were hit or assaulted by a student who was under the influence of alcohol." While previous studies have looked at the connection between average college alcohol consumption and physical injury, or at the relationship between frequency of binge drinking (defined as 5+ drinks for males/4+ drinks for females) and injury, he explained, this study examined the combined "dose-response" effects of drinking quantities and frequencies on college alcohol-related injury risk. Mundt and his colleagues initially surveyed 12,900 college students seeking routine care in five college health clinics on alcohol use and other health risk behaviors. Of these, 2,090 who exceeded at-risk levels of alcohol consumption agreed to participate in face-to-face interviews to determine eligibility for a randomized controlled trial of brief alcohol-intervention. The interview assessed previous 28-day alcohol use, as well as alcohol-related injuries in the preceding six months. "Compounding the risk of multiple days of heavy drinking, students who drank 8+ drinks for males or 5+ drinks for females on at least four days per month, for example, every weekend, were five times more likely to be injured than those who did not frequently cross the 8+ M/5+ F drinking limit," said Mundt. "In addition, students who scored high on sensation-seeking disposition also experienced greater risk for alcohol-related injuries." He added that prior research had shown that a sensation-seeking disposition is linked to alcohol-related injuries treated at hospital emergency rooms, and also linked to alcohol-impaired driving. "College administrators, parents, and clinicians need to focus their intervention efforts on these students - "frequent extreme heavy drinkers" - who score high on sensation-seeking disposition," said Mundt. "These are the students at high risk for injury. Quantities alone, or frequency of consumption alone, do not show the whole picture. A drinking pattern of frequent extreme intoxication is key, as it escalates injury rates rapidly." Marlon P. Mundt, Ph.D. University of Wisconsin-Madison Alcoholism: Clinical & Experimental Research


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