Popular Articles
Teeth Whitening Products

Change4Life Corner Shops To Open Across The Country, UK
Corner shops nationwide will get help from Change4Life to sell fruit and veg - this will mean more people will get their 5 a day and shops will see an increase in profits, Secretary of State for Health Andy Burnham said today.
generic viagra online
Fasting During Ramadan Is Safe For Stroke Patients
Physiological and biochemical changes that occur during fasting in Ramadan are not a risk factor for stroke and do not affect the short-term survival of patients. This is the result of a study by a team of researchers from the Isfahan University of Medical Sicences (Iran). The data are being presented at the annual meeting of the European Neurological Society in Milan (Italy).
News of the day
Family Physician Survey In Mainz: Patients With Depression Frequently Suffer From Medically Unexplained Pain
Pain symptoms that cannot be attributed, or at least not fully attributed, to an organic origin are more frequently and more severely experienced by patients with depression than by those without. "It is the case that women are much more frequently affected by depression and also by so-called somatoform pain disorder than men," explains Dirk Frieser, psychologist at the Institute of Psychology at Johannes Gutenberg University Mainz. For the purposes of his doctoral dissertation, Frieser and fellow psychologist Stephanie Kç¶rber questioned 308 patients attending two practices of general practitioners in Mainz. Patients were asked about their state of health and their pain symptoms, but also about their anxieties with regard to illness, how they react when ill, what social support they receive, and what psychological stress they experience, together with many other aspects. Subsequently, the pain symptoms reported by the patients were evaluated by their doctors.
Nutrition

The Downside Of Microtubule Stability - Study Shows Stalled Microtubules Might Be Responsible For Some Cases Of Charcot-Marie-Tooth Disease

Stalled microtubules might be responsible for some cases of the neurological disorder Charcot-Marie-Tooth (CMT) disease, Tanabe and Takei report in the June 15, 2009 issue of the Journal of Cell Biology. A mutant protein makes the microtubules too stable to perform their jobs, the researchers find. The mutations behind CMT disease slow nerve impulses, reduce their strength, or both. One of these mutations leads to production of faulty dynamin 2, a protein that is crucial for endocytosis but also latches onto microtubules. Tanabe and Takei investigated how defective dynamin 2 hampers cells. Normal microtubules are continually extending and shrinking. But microtubules from cells that made the faulty version of dynamin 2 were abnormally stable, as measured by how many acetyl groups were attached to them. The researchers also found that blocking normal dynamin 2 with RNAi had the same effect as the mutation, confirming that one of dynamin 2"s functions is to promote microtubule turnover. Removing dynamin 2 shattered the Golgi complex, Tanabe and Takei discovered. Dynamic microtubules help construct the Golgi complex in two ways: they capture the vesicles that combine to form a mature Golgi complex; and they provide a track along which these vesicles can travel to their rendezvous point near the nucleus. By breaking up the Golgi apparatus and then watching the fragments reunite, the researchers found that dynamin 2 was essential for the capture step, not for transportation. Dynamin 2 also clings to microtubules of the mitotic spindle, and the team next wants to determine whether the protein regulates microtuble dynamics during the cell cycle. Notes: About the Journal of Cell Biology Founded in 1955, the Journal of Cell Biology (JCB) is published by the Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JCB content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit http://www.jcb.org or visit the JCB press release archive at http://www.eurekalert.org/jrnls/rupress. Tanabe, K., and K. Takei. 2009. J. Cell Biol. doi:10.1083/jcb.200803153. Rita Sullivan Rockefeller University Press


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):