Diagnostics
Australia"s general practices stand ready to work with Government to begin vaccinating vulnerable Australians against HINI (Swine Flu) as soon as a vaccine becomes available, the AMA said today.
Health plans launched a new national television advertising campaign in support of bipartisan health care reform.
In 1989 scientists identified the gene mutation that causes cystic
Surgically removing and evaluating an increasing number of lymph nodes does not appear to identify a greater number of patients with stage III colorectal cancer, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.
Two and a half years after children with sleep-related breathing disorders had surgery to remove their tonsils and adenoids (glands in the back of the throat), they appear to sleep better than they did before the procedure but not as well as they did six months after, according to a report in the July issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals. Initial improvements in their behavior were maintained except when measured by an index of attention-deficit/hyperactivity disorder (ADHD) symptoms.
Should the financial ties between doctors and drug companies be completely
In response to Food Standards Agency"s new guidelines on voluntary salt reduction targets, Alex Callaghan, Policy Officer at the British Heart Foundation (BHF), said:
Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN), Eli Lilly and Company (NYSE: LLY) and Alkermes, Inc. (Nasdaq: ALKS) today announced positive results from a study comparing subjects randomized to either exenatide once weekly or Lantus® (insulin glargine). Patients randomized to exenatide once weekly experienced a statistically superior reduction in A1C, a measure of average blood sugar over three months, of 1.5 percentage points from baseline, compared to a reduction of 1.3 percentage points for Lantus after completing 26 weeks of treatment. At the end of the study, patients treated with exenatide once weekly achieved a mean A1C of 6.8 percent compared with a mean A1C of 7.0 percent in those treated with Lantus. Treatment with exenatide once weekly also produced a statistically significant difference in weight, with a mean weight loss of 5.8 pounds at 26 weeks, compared with a mean weight gain of 3.1 pounds for Lantus, a difference of 8.9 pounds between the treatments.
Following the disbandment of the STEP trial to test the efficacy of the Merck HIV-1 vaccine candidate in 2007, the leading explanation for why the vaccine was ineffective - and may have even increased susceptibility to acquiring the virus - centered on the hypothesis that high levels of baseline Ad5-specific neutralizing antibodies may have increased HIV-1 acquisition among the study subjects who received the vaccine by increasing Ad5-specific CD4+ T-cells that were susceptible to HIV-1 infection.
A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer, Medical College of Georgia researchers say.
The Aeras Global TB Vaccine Foundation (Aeras) has announced a new collaboration with The Aurum Institute on the first study to test the AERAS-402/Crucell Ad35 tuberculosis (TB) vaccine candidate for safety in people living with the human immunodeficiency virus (HIV). Aurum will conduct this trial in people living with HIV at its clinical trial site near Johannesburg, South Africa. The Medicines Control Council of South Africa and two Independent Ethics Committees in South Africa have given approval to test the vaccine in South Africa. AERAS-402/Crucell Ad35 has been previously tested for safety in healthy adults in the United States and HIV-negative adults and infants in South Africa.
University of Queensland researchers will use a $2.5 million grant to help people who have suffered an acquired brain injury communicate with the world.
Ardea Biosciences, Inc. (Nasdaq:RDEA) today announced that it has initiated a Phase 2b clinical trial of RDEA594, its lead product candidate in development for the management of hyperuricemia and gout. The Company also announced the selection of RDEA684, a next-generation URAT1 inhibitor, as a development candidate for the same indication.
Oramed Pharmaceuticals, Inc. (OTCBB: ORMP.OB), a developer of alternative drug delivery systems, today reported positive results from a Phase 2A study of its oral insulin capsule, ORMD-0801, on type 1 diabetic patients. The completion of this study marks Oramed"s first clinical trial on patients with Type 1 Diabetes Mellitus, whereas, all Oramed"s trials up to date have been conducted on type 2 diabetic patients. This study evaluated safety, tolerability, and food effects in type 1 diabetic patients.
Across the state of Maryland, there are now doctors and nurses, freshly trained in pediatric dental health care, who can help stem an alarming number of 3-year-old children who arrive for their first dentist visit with teeth "just melting away."
Two large US studies published in a leading journal this month support the already substantial body of evidence that shows choosing to follow a
Four newspapers recently published editorials responding to last week"s confirmation hearings for Supreme Court nominee Sonia Sotomayor. Summaries appear below.~ Boston Globe: Sotomayor "far surpassed" the "meager standard" of "just [having] to avoid saying anything damaging," according to a Globe editorial. During the hearings, she "made it clear she believes that Supreme Court justices base their decisions on the Constitution, the law and the relevant precedents," and her "judicial record offers no reason to think otherwise," the editorial states. It continues that "the hearings did nothing to undermine -- and much to underscore -- the notion that Sotomayor has the right temperament, intellect and credentials for the Supreme Court. She should be confirmed" (Boston Globe, 7/20).~ New York Times: The Senate "has learned more than enough about [Sotomayor"s] qualifications to give her a seat on the court," according to a Times editorial. However, "[i]t would also be good if senators -- and the nation -- had a deeper sense of her views on some of the most pressing legal questions of our times," the editorial continues. It adds, "We were disappointed that at her confirmation hearings last week, she continued what is becoming an unbreakable habit of nominees dodging controversy." For example, "[w]e would have liked to hear her boldly defend the idea of the Constitution as a living document, one that changes with the times," and "we would have preferred if she had used the hearings to explain to the public that the much-mentioned distinction between judges making and applying the law has little meaning," the editorial states. Sotomayor "avoided saying much of substance about abortion rights, the scope of presidential power, and other hot-button issues," although this is "not entirely her fault," as the "Senate has shown repeatedly that it will tolerate this sort of evasion." However, "the public has a right to know where judicial nominees stand on important legal issues that will have a direct impact on their lives," the editorial states. It concludes, "We hope the Senate confirms her without delay so we can see more clearly what her contribution will be" (New York Times, 7/21).~ Washington Post: During her confirmation hearings, Sotomayor "proved herself well-qualified and worthy of confirmation," according to a Post editorial. The editorial continues, "She spoke convincingly about her belief in and record of consistently respecting legislative prerogatives -- an approach that signals a modest style of judging." Although the hearings focused on Sotomayor defending her previous speeches and comments, her "attempts to explain away and distance herself" from the statement that a wise Latina might make a better decision than a white man "were unconvincing and at times uncomfortably close to disingenuous, especially when she argued that her reason for raising questions about gender or race was to warn against injecting personal biases into the judicial process." The editorial adds, "Her repeated and lengthy speeches on the matter do not support that interpretation." According to the Post, "It"s too bad that she felt she had to disavow her true intent, because, though a wise Latina won"t necessarily judge better than a white man would, diversity on the bench is indeed important" (Washington Post, 7/19).~ Washington Times: During the hearings, Republican senators "failed to ask questions of great relevance to public understanding of the judge"s record and integrity," a Times editorial states. The editorial continues, "They owe it to all Americans to get tough enough to force an examination of whether the judge may have perjured herself during her testimony." According to the editorial, "The questions for which Judge Sotomayor"s answers are almost impossible to believe involved legal briefs on abortion cases that were filed by the Puerto Rican Legal Defense and Education Fund during the 12 years Judge Sotomayor sat on its board." Republican senators also "failed to ask sharp f
New York Gov. David Paterson (D) should sign a bill prohibiting the "barbaric and medically hazardous practice of shackling female prisoners during labor," a New York Times editorial states. Along with "further frightening these vulnerable women, the practice of chaining their legs, wrists and even their abdomens" during labor "makes treatment and delivery more difficult and places mother and child at greater risk of harm," according to the Times. It adds that five states have similar policies in place. The American College of Obstetricians and Gynecologists several years ago called for an end to shackling during labor, and the Federal Bureau of Prisons last fall "ended the routine use of restraints for women in labor and limited shackling to cases in which a woman presents a danger to herself, the baby or the staff," the editorial states.The New York measure, which is "[m]odeled on federal prison policy and laws in other states, … would prohibit women from being shackled while being taken to the hospital for a delivery," although an inmate "could be cuffed by one wrist in cases in which she presented a danger to herself, hospital staff or corrections workers," the editorial states. However, "it seems highly unlikely that a woman doubled over in labor pains would be able to attempt an escape or overcome corrections officers," it notes.The bill "has caused a debate about how many pregnant women are actually shackled in New York," but "recent interviews of female inmates by the Correctional Association of New York … sugges[t] that the practice may be more common than corrections officials know," the editorial continues. "In any case, the bill would put an end to it, by establishing clear guidelines that carry the authority of law," according to the editorial. It adds that Paterson "should make it clear whether he thinks the measure needs minor changes or clarifications." The editorial concludes, "Otherwise, he should sign the bill into law" and "bring New York into line" with the federal government and other states "that have wisely acted to protect pregnant inmates and their children during labor" (New York Times, 7/21).
Sufferers of eating disorders have problems with certain mental tasks; this is the finding of a comprehensive overview of studies examining the link between cognitive deficits and eating disorders, published online in the Journal of Neuropsychology today, 22nd July 2009.
AccuVein LLC announced the launch of AccuVein AV300, the world"s first hand-held, non-contact vein illumination device that helps healthcare professionals locate hard-to-find veins. IV starts and blood draws (venipuncture) can be a of patient anxiety and discomfort, and accessing veins in difficult patients can take up to 10 minutes and require multiple needle sticks. Venipuncture is the most common invasive medical procedure with an estimated 2.7 million procedures conducted every day in the United States alone. The AV300 can help reduce the need for multiple needle sticks, with the goal of improving patient care and the time to access veins.
A former health insurance spokesman speaks out against insurance practices. The Wall Street Journal/Dow Jones reports: "Wendell Potter, former chief spokesman for health insurer Cigna Corp., describes himself in his Twitter bio as a "journalist who spent 20 years undercover as HMO PR flack, now writing all about it." While Potter chuckles about the line, he is serious about his foray into the U.S. health reform debate, where he is campaigning for a public health-plan option and, with mild delivery and tough words, targeting what he calls "deceptive and dishonest" tactics of a for-profit health insurance industry that"s fighting such a plan."
Vesselplasty, a new minimally invasive procedure, increases mobility and reduces pain and the need for pain killers in patients with vertebral compression fractures (VCFs), according to a study performed at the Hospital Universitario Doctor Peset, Valencia, Spain. Vesselplasty is a new alternative to vertebroplasty and kyphoplasty-two conventional VCF treatment methods. Vesselplasty solves the problem of leakage of cement out of the vertebral body which can happen during both vertebroplasty and kyphoplasty," said Lucia Flors, MD, lead author of the study.
Over 30 of the UK"s leading scientists have signed an open letter to the government calling for more public money to back research into dementia,
Nigeria on Monday signed on to receive a $100 million loan from the World Bank for malaria control activities, Leadership Nigeria reports. The states of Akwa Ibom, Anambra, Bauchi, Gombe, Jigawa, Kano and Rivers will receive part of the funding for malaria control activities (Nduwugwe, 7/21).World Bank Country Director for Nigeria Onno Ruhl signed the agreement on behalf of the bank and Nigerian Finance Minister Sarki Muhtar signed on behalf of the federal government. Ruhl said the World Bank is "confident" in Nigeria"s ability to fight malaria, This Day writes. Ruhl pointed out that during President Barack Obama"s recent trip to Ghana, he "commended" Nigeria"s interfaith efforts for fighting malaria.
Health reform legislation moving through the U.S. House of Representatives would reverse the continued and growing loss of health coverage by American families and would give millions of Americans the security of stable, quality, affordable coverage, according to a report released today by the consumer health organization Families USA.
The Medical Research Council has announced funding for seven awards totalling ÷£4.7 million under its translational stem cell research scheme. This includes nearly ÷£3 million for four early stage clinical trials involving adult stem cells.
The hospitalization rate of patients admitted for treatment of hip, pelvis and other fractures associated with osteoporosis increased by 55 percent between 1995 and 2006, according to the latest News and Numbers from the Agency for Healthcare Research and Quality.
Genetic testing services have recently begun to be advertised directly to the patient, and the results of the consumers" response can affect public health, as well as the future adoption of pharmacogenetic/genomic testing, according to a position paper from the American College of Clinical Pharmacology (ACCP) to be published in the August 2009 issue of the Journal of Clinical Pharmacology. The journal is published on behalf of the ACCP by SAGE.
Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University"s Feinberg School of Medicine and a researcher in the Human Molecular Genetics Program of Children"s Memorial Research Center studies a gene that is involved in susceptibility to schizophrenia, Disc1 (Disrupted-In-Schizophrenia 1). Two recent publications by Morris and colleagues focus on the role of Disc1 in development, particularly the migration of cells to their proper location in the brain and subsequent differentiation into their intended fate. During development, cells need to properly migrate to their final destination in order to develop into the appropriate cell-type, integrate into the corresponding network of cells and function properly. Disruption of cell migration can lead to inappropriate cell development and function, resulting in disease.
Foresight Biotherapeutics, Inc. announced completion of a multi-center open-label pilot study of FST100 in the treatment of viral conjunctivitis. FST-100 is a novel formulation of dexamethasone that includes povidone iodine. The trial studied patients with clinical signs and symptoms of acute conjunctivitis who tested positive for adenoviral antigen by the RPS Adeno Detector® (RPS). Patients were enrolled in a single arm utilizing FST-100 topical ophthalmic suspension given 4 times daily for 5 days. The RPS Adeno Detector® test was performed at baseline and at each visit along with conjunctival swabs for adenoviral titers by quantitative PCR (qPCR) and cell culture with confirmatory immunoflourescence (CC-IFA). The primary endpoint of the study was clinical resolution of conjunctival injection and conjunctival discharge. These signs were scored on a scale from zero to three. Secondary endpoints included reduction of viral titers measured by qPCR and eradication of infectious virus determined by CC-IFA.
In the July issue of Biomaterials, published by Elsevier, researchers from the University of Central Florida (UCF) report on the first lab-grown motor nerves that are insulated and organized just like they are in the human body. The model system will drastically improve understanding of the causes of myelin-related conditions, such as diabetic neuropathy and later, possibly multiple sclerosis (MS). In addition, the model system will enable the discovery and testing of new drug therapies for these conditions.
The Diabetes UK Media Relations Team has been shortlisted as one of five finalists for The Third Sector Excellence Awards in the category of Communications Team.
Apieron, Inc. said that CareFirst BlueCross BlueShield has adopted a positive coverage policy for the measurement of exhaled nitric oxide (eNO). The Medical Directors of CareFirst determined that the published, peer-reviewed evidence is sufficient to support benefit coverage for the treatment of asthma. The policy, effective July 20, 2009, states the measurement of exhaled nitric oxide is considered medically necessary in the management of asthma patients. CareFirst is the largest health care insurer in the Mid-Atlantic region, serving nearly 3.4 million members in Maryland, District of Columbia and portions of Virginia.
Cell Therapeutics (CTI) (Nasdaq and MTA: CTIC) announced that researchers from the Laboratory of Molecular Pharmacology at the National Cancer Institute presented new preclinical research identifying unique anti-tumor mechanisms of brostallicin that sets this agent apart from other currently used chemotherapy agents. CTI acquired worldwide rights to brostallicin when it acquired privately-held Systems Medicine LLC in 2007. Published in the journal Molecular Cancer Therapy (Mol Cancer Ther 2009;8(7) July 2009; 1985-94), the researchers utilized preclinical studies to provide clues into tumor susceptibility mechanisms for brostallicin, a synthetic DNA minor grove binder, and to identify differences between brostallicin and trabectedin (Yondelis(R); ET-743), which is a natural marine product approved in Europe. Unlike other chemotherapy agents, including trabectedin, the NCI research indicates that the tumor cell DNA damaging effects of brostallicin are enhanced by high tumor glutathione levels, a hallmark of drug-resistant tumors. Brostallicin was shown to affect DNA in both dividing and quiescent cells. Its actions can be followed by induction of a specific DNA binding protein foci that can be detected in circulating blood cells. Importantly, brostallicin was active in a trabectedin-resistant cell line.
A new survey, released today by The Senior Citizens League (TSCL), found that senior citizens are being forced to make drastic cuts to their medical and food budgets due to the recession.
Research presented at the American Association for Clinical Chemistry annual meeting shows that an assay developed by Abbott for simultaneous detection of both HIV antigens and antibodies reduced the detection window by zero to nine days in this study compared to HIV antibody-only assays. Earlier detection was shown on four of the five panels tested.
Women who underwent radiation therapy for cancer as children have an increased long-term risk for developing breast cancer, according to a study published in the Journal of Clinical Oncology, Reuters reports. However, when the childhood treatments included a high dose of radiation to the ovaries, women"s risk of developing future breast tumors was "sharply reduced," according to the study.For the study, Peter Inskip of the National Cancer Institute and colleagues examined 120 women diagnosed with cancer before age 21. All women in the study were treated with radiation between 1970 and 1986 and survived at least five years. The women were compared with four women who also were diagnosed at a young age but did not receive radiation.The study found that the more radiation a woman received as a child, the more likely it was that a tumor would eventually develop. The study did not find that chemotherapy for the first cancer increased the risk for a second cancer (Reuters, 7/20).
Cancer stem-like cells have been implicated in the genesis of a variety of malignant cancers. Research scientists at Cedars-Sinai Medical Center"s Maxine Dunitz Neurosurgical Institute have isolated stem-like cells in benign (pituitary) tumors and used these "mother" cells to generate new tumors in laboratory mice. Targeting the cells of origin is seen as a possible strategy in the fight against malignant and benign tumors.
Over the last four years, heart specialists at NewYork-Presbyterian Hospital/Columbia University Medical Center have implanted an innovative aortic heart valve replacement using a catheter-based approach that does not require open-heart surgery in a total of 100 patients -- the most of any U.S. medical center to date.
Topical Treatment Improves Wound Healing
The 2009 Cancer Congress Update held at the Park Plaza hotel in central London was hailed a resounding success by clinicians from the worlds of breast, colorectal, lung, prostate and haematological cancer.
The European Medicines Agency has been formally notified by Gendux
The government launches New Horizons, a major new consultation on how we should care for the mental health of the nation for the next ten years. As the current mental health strategy the National Service Framework draws to a close this autumn, New Horizons is a pivotal opportunity to move on from a model of mental health care based solely on delivering medical services, to a cross-government plan that approaches everyone"s mental wellbeing holistically, and considers the impact of social factors such as unemployment and debt.
Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) announced that the Ministry of Health, Labour and Welfare (MHLW) in Japan has approved Nexavar(R) (sorafenib) tablets for the treatment of patients with unresectable hepatocellular carcinoma (HCC), a type of liver cancer that accounts for 95 percent of all liver cancer cases in Japan(1). Nexavar is also currently available in Japan as an approved treatment for unresectable or metastatic renal cell carcinoma (RCC).
Injured heart tissue normally can"t regrow, but researchers at Children"s Hospital Boston have now laid the groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects. In the July 24 issue of Cell, they show that a growth factor called neuregulin1 (NRG1), which is involved in the initial development of the heart and nervous system, can spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a heart attack.
Responding to data in Smoking, drinking and drug use among young people in England, 2008 that suggests the likelihood of a pupil drinking alcohol increases with the number of drinkers per household, Professor Ian Gilmore, President of the Royal College of Physicians said:
Experiencing chronic stress day after day can produce wear and tear on the body physically and mentally, and can have a detrimental effect on learning and emotion. However, acute stress -- a short stressful incident -- may enhance learning and memory.
As healthcare reform becomes an increasing national priority, the American Psychological Association (APA) and YMCA of the USA announced a partnership that provides strategies to help families improve their overall well-being and physical health, and advocates for a comprehensive healthcare system that has a strong approach to chronic disease prevention. The partnership will specifically address the impact individual behaviors such as eating healthy and increasing physical activity can have in reducing risk factors for chronic diseases.
The Australian Nursing Federation (ANF) welcomes the Federal Government"s announcement of funding to upgrade the skills of workers in aged care.
A protein from algae may have what it takes to stop Severe Acute Respiratory Syndrome (SARS) infections, according to new research. A recent study has found that mice treated with the protein, Griffithsin (GRFT), had a 100 percent survival rate after exposure to the SARS coronavirus (SARS-CoV), as compared to a 30 percent survival for untreated mice.
"Will failing to reform health care have the same consequences for Obama"s administration as it did for Clinton"s?" CNN asks.
Several analyses today on the Congressional Budget Office, and its director, Douglas Elmendorf, who has been at the center of increasing debate over health care reform after the recent release of the CBO"s "score" of health system overhaul legislation. President Barack Obama met with him Monday in a move that has spurred Republican criticism.
Congress is starting to tackle long-term care through a measure for a national long-term insurance program, according to the New York Times The New Old Age blog.
A study conducted by the American Society of Clinical Oncology (ASCO) finds that different interpretations of the U.S. Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule can result in significant delays or abandonment of important clinical cancer research projects. The study also outlines measures that research sites can undertake to resolve these differences and speed the pace of research. The study results were published online today by the Journal of Clinical Oncology in an ASCO special article, "The Impact of the Privacy Rule on Cancer Research: Variations in Attitudes and Application of Regulatory Standards".
The U.S. Department of Energy"s Brookhaven National Laboratory and Hybridyne Imaging Technologies, Inc., of Toronto, Canada, have won a 2009 R&D 100 Award for developing a compact gamma camera for high-resolution imaging of prostate cancer. The camera system, called ProxiScan, is a nuclear medical instrument that can localize cancer tissue in the prostate gland in detail at an early stage, which is important for the successful diagnosis and early treatment of the potentially deadly disease.
Using high-speed cinematography, scientists at Cambridge University have discovered that individual algal cells can regulate the beating of their flagella in and out of synchrony in a manner that controls their swimming trajectories. Their research was published on the 24th July in the journal Science.
US researchers have created "bacterial computers" with the potential to solve complicated mathematics problems. The findings of the research, published in BioMed Central"s open access Journal of Biological Engineering, demonstrate that computing in living cells is feasible, opening the door to a number of applications. The second-generation bacterial computers illustrate the feasibility of extending the approach to other computationally challenging math problems.
Women who are at risk for heart disease and who are also experiencing menopause symptoms now have an added re a highly specialized clinic in the Division of Cardiology at the Cedars-Sinai Heart Institute. The Advanced Preventive Women"s Clinic at the Women"s Heart Center recently opened and is offering comprehensive cardiac risk assessments designed specifically for women who are in menopause. The clinic also offers menopausal patients state-of-the-art screenings, as well as personalized medicine therapies and counseling, including high-risk hormone counseling.
Use of the medication tamsulosin to treat male urination difficulties within two weeks of cataract surgery is associated with an increased risk of serious postoperative ophthalmic adverse events such as retinal detachment or lost lens, according to a study in the May 20 issue of JAMA.
Australia"s largest study of young drivers has shown that risky driving habits are putting young drivers at a significantly increased risk of crashing, irrespective of their perceptions about road safety. The study surveyed 20,000 young drivers and examined their crashes reported to police. Young drivers involved in the study who said they undertook risky driving were 50% more likely to crash.
Scientists at Glasgow have made a significant discovery in the study of a rare form of diabetes which predominantly affects men. Hereditary Diabetes Insipidus is, according to experts, the most common genetic disease known in medicine. It causes serious kidney malfunction and can, if untreated, be fatal. There are an estimated to be around 9000 Heredirary DI patients in the UK.
VistA Imaging, the medical and health care imaging system used in Department of Veterans Affairs (VA) medical centers, attained over one billion stored images in January this year, according to the department.
As the economy continues to falter, a poll released today shows that parents must make harder choices about how to spend what money they have, and children -- especially those who are uninsured or who are among the lowest income bracket -- are more at risk because of it.
Breathing xenon gas can help protect the infant brain from damage caused by oxygen deprivation, but the xenon"s high cost and scarcity has precluded its widespread use. A newly developed "closed circuit system" may make xenon feasible, safe, and cost efficient for use in protecting the brains of critically ill infants, according to a study in the August issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, pharmacy and the pharmaceutical industry.
The Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMEA), has adopted a negative opinion for the use of Erbitux® (cetuximab) in combination with platinum-based chemotherapy for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, advanced or metastatic non-small cell lung cancer (NSCLC). Merck KGaA is evaluating potential appeal options requesting that the CHMP re-examine data demonstrating clinical relevant benefits to patients.
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its wholly owned subsidiary, BiPar Sciences, announced the initiation of the pivotal Phase III trial for BSI-201 in combination with chemotherapy in patients with metastatic triple-negative breast cancer (mTNBC), defined by tumors lacking expression of estrogen, progesterone receptors and without over-expression of HER2. BSI-201 is a novel investigational targeted therapy which inhibits poly (ADP-ribose) polymerase (PARP1), an enzyme involved in DNA damage repair.
When the number of red blood cells or concentrations of hemoglobin are low a person is said to have anemia. Hemoglobin is a protein (metalloprotein) inside the red blood cells that contains iron and transports oxygen.
Astigmatism is an eye condition with blurred vision as its main symptom. The front surface of the eye (cornea) of a person with astigmatism is not curved properly - the curve is irregular - usually one half is flatter than the other - sometimes one area is steeper than it should be.
NPR reports on one of the most powerful players in health care: the Pharmaceutical Research and Manufacturers of America, or PhRMA. In addition to spending $40 million, PhRMA alone has 29 people lobbying for it and has "hired 45 different Washington, D.C., lobbying firms to represent it in those three months of the second quarter."
An amendment to the fiscal year 2010 appropriations bill for health, labor and education programs that opposes the lifting of the ban on federal funding for needle exchange programs will come to the House floor for debate today along with four others, CQ Today reports. Rep. Mark Souder (R-Ind.) "will offer an amendment to strip language that would lift the ban on federal funding for needle exchange programs," CQ writes. According to CQ Today, "Conservatives are concerned that eliminating the ban on federal funds for such programs, which are designed to reduce the transmission of HIV and other diseases, would be tantamount to helping fund addicts" drug habits. Democrats say science has shown that such programs, when coupled with comprehensive prevention strategies, can reduce the rate of [HIV] infections and do not promote drug use." House Appropriations Committee Chair David Obey (D-Wis.) "added compromise language in the committee this week that would prohibit funds from going to needle exchange programs within 1,000 feet of facilities that serve children, such as schools and parks," the article states. The House is expected to vote on the amendment and the appropriations bill today (Wolfe, 7/23).
The air in Beijing during the 2008 Olympics was cleaner than the previous year"s, due to aggressive efforts by the Chinese government to curtail traffic, increase emissions standards and halt construction in preparation for the games, according to a Cornell study.
Overall prognosis for gallbladder cancer appears to be improving, although many patients still have incurable disease and poor survival rates, according to a report in the May issue ofArchives of Surgery, one of the JAMA/Archives journals.
The California Medical Association expressed grave concerns about the budget passed by the Legislature, pointing to deep cuts in Medi-Cal and the Healthy Families Program that will deny hundreds of thousands of the state"s most vulnerable residents - children, the elderly and the poor - from getting the health care they need.
Kristen Parker, a former Rose Medical Center surgery "scrub" technician, was indicted by a federal grand jury in Denver, announced David Gaouette, Acting U.S. Attorney, Stephen Holt, Special Agent in Charge of the FDA Office of Criminal Investigations, Kansas City Field Office, and Jeffrey Sweetin, Special Agent in Charge of the Drug Enforcement Administration Denver Division. Parker, age 26, of Elizabeth, Colorado, was named in a 42 count indictment charging product tampering and obtaining controlled substances by deceit. She remains in federal custody, being held without bond pending a resolution of her case.
83% of young people surveyed by UNICEF UK and Terence Higgins Trust say they need a sexual health information service similar to the Government"s "Talk to Frank" drugs service.
A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson"s disease for Vietnam veterans. The report is the latest in a congressionally mandated series by the IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin -- TCDD -- that contaminated some of the defoliants.
HHS Secretary Kathleen Sebelius congratulated the National Conference of State Legislatures (NCSL) after the conference approved an amendment in favor of health insurance reform. The amendment was approved by a vote of 38-11. According to NCSL rules, amendments must receive 75 percent of the vote in order to pass.
African-American adolescents have some of the highest rates of HIV infection in the United States, and efforts to educate them about preventing the disease must include the help of their adolescent peers, new research suggests.
In recent years, oncologists have debated whether patients with a certain type of advanced lung cancer would benefit from surgery.
Elekta (STO:EKTAB) has received FDA 510(k) clearance for the VMAT (Volumetric Modulated Arc Therapy) enhancement to Monaco®, treatment planning solution.
In light of health care reform measures, Rush University Medical Center has launched a study of its program to help older adults transition from hospital to home.
A group of UQ speech pathology students recently ran an intensive treatment program for people who stutter.
Relistor (Methylnaltrexone) is a medication for patients who suffer from constipation caused by opioid drugs. Opioid drugs are used for pain relief. An opioid is a chemical that binds to opioid receptors that exist mainly in the central nervous system and the gut (gastrointestinal tract). When people take opioids they have a lower perception of pain, a lower reaction to pain, as well as a higher pain tolerance - in other words, opioids provide effective pain relief. However, opioids also cause constipation.
A preliminary hearing for Scott Roeder, the man charged with the May 31 murder of Kansas abortion provider George Tiller, is set for Tuesday, the AP/Houston Chronicle reports. During the hearing, prosecutors will attempt to convince a judge they have enough evidence for a trial, according to the AP/Chronicle.Roeder is charged with one count of first-degree murder in Tiller"s death, as well as two counts of aggravated assault for allegedly threatening two ushers who tried to stop him from shooting Tiller in the foyer of his Wichita church. According to the AP/Chronicle, Roeder will enter a plea if the judge determines that the case can go to trial. He has not indicated what plea he intends to enter should that occur (Hegeman, AP/Houston Chronicle, 7/26).In related news, the New York Times on Sunday examined the life and career of Tiller, who was one of the few abortion providers who performed the procedure later in pregnancy. Throughout Tiller"s career -- which began in the 1970s -- he "made himself the nation"s pre-eminent abortion practitioner," according to the Times. In addition, antiabortion-rights advocates made his clinic the "most visible abortion battleground" in the U.S., as well as "a magnet for activists from all corners of the country," the Times reports. However, Tiller "would not budge" and "[wore] their contempt as a badge of honor." According to the Times, employees at the clinic said Tiller believed his work saved women"s lives and ensured their right to an abortion. "We have made higher education possible," Tiller said in a speech, adding, "We have helped correct some of the results of rape and incest. We have helped battered women escape to a safer life. We have made recovery from chemical dependency possible. We have helped women and families struggle to save their unwell, unborn child after a lifetime of pain."According to the Times, advocates on both sides of the abortion-rights debate "have been measuring the larger ramifications" of Tiller"s murder. Abortion-rights opponents are "bracing for a drop in support, especially from those in the murky middle ground of the debate." Abortion-rights supporters, on the other hand, are "reeling from the loss of one of their most experienced and savviest leaders," the Times reports. The article also examined Tiller"s career choice, tactics employed by abortion-rights opponents and some of the legal challenges Tiller faced (Barstow, New York Times, 7/26). In addition, the Times on Sunday included an online discussion and slide show involving a man and woman with differing views on abortion rights (New York Times, 7/26).Meanwhile, the Kansas City Star on Sunday included an interview with Roeder, during which he said he was "elated" that Tiller was dead and that he considers killing abortion providers to be justifiable homicide. In the interview, Roeder said that "[n]obody was willing to do anything" about the abortions performed at Tiller"s clinic, adding that it is wrong "for society to allow such an egregious sin to go on." Roeder also discussed his actions on the day of the murder, his past dealings with the antiabortion-rights movement and his possible trial strategy (Thomas, Kansas City Star, 7/26).
A leading Democratic senator, Kent Conrad, D-N.D., said Sunday Democrats would need Republican support to make ambitious proposals to overhaul the health system a reality, the Associated Press reports. "Look, there are not the votes for Democrats to do this just on our side of the aisle," said Conrad, who chairs the Budget Committee. Democrats remain divided over the plans, prompting the Republican leader, Sen. Mitch McConnell, R-Ky., to say, "The only thing bipartisan about the measure so far is the opposition to it" (7/26).
Covering the uninsured - a leading principle of health care reform - depends on the critical issue of who gets subsidies to pay for health insurance coverage and when.
"Massachusetts legislators this year have filed a flurry of bills - more than 70 in all - that, if passed, would substantially expand the medical services insurers are required to cover for patients but also potentially raise healthcare costs," The Boston Globe reports. "The cascade of proposals to mandate coverage is up 50 percent from last year, and comes amid unprecedented scrutiny of healthcare spending. Among the bills are proposals to mandate coverage of hearing aids for children, treatments to fix cleft palates, wigs for patient who suffer "hair loss from cancer and other illnesses," and aquatherapy." Some say this level of activity may be caused by patient advocates "racing to get their health concerns covered by law before the state"s system for paying doctors and hospitals is overhauled." But given the state"s current budget difficulties, "it"s uncertain how many of the bills will make it into law" (Lazar, 7/27).
Congressional Republicans are releasing two health care reform proposals -- one from conservatives and one from moderates -- as alternatives to plans by Democrats, CQ Today reports (Wayne, CQ Today, 5/19). Conservative Plan
The Washington Post on Sunday featured Washington D.C.,-based Inner Light Ministries, a 16-year-old black community church with about 100 members, where many go "to share their experience of being black and gay, living and loving in a city where HIV and AIDS lurk in epidemic proportions. ò€¦" Some members of the congregation, as well as four of its leaders including Bishop Rainey Cheeks are HIV-positive. Cheeks teaches safe sex as a part of his sermons and the church provides condoms to its members. The article also discusses the stigma associated with HIV among gay black men. "Some men are reluctant to reveal their health status to possible partners for fear of being rejected," according to the Post. "That attitude, Cheeks said, is part of why gay black men in the District are disproportionately affected by HIV and AIDS. And why he has to keep preaching the message of safe sex," the article states (Fears, 7/26).
The AMA has congratulated the National Health and Hospitals Reform Commission on its final report launched in Canberra by Prime Minister Kevin Rudd.
A comprehensive analysis of nearly 1,600 tumor samples has found that CT-X genes are expressed in nearly half the breast cancers that lack the estrogen receptor (ER). CT-X gene products are the targets of therapeutic cancer vaccines already in phase III clinical trials for lung cancer and melanoma. The study - to be published in the Early Edition of the Proceedings of the National Academy of Sciences this week - was led by the international Ludwig Institute for Cancer Research (LICR).
Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), July 28 - August 1, 2009, the foremost society for research into all aspects of eating and drinking behavior, finds that women who possess genetic modifications associated with low activity of the reward neurotransmitter dopamine in the brain when they imagine eating appetizing foods are more prone to weight gain. Functional Magnetic Resonance Imaging (fMRI) scans of brain activity revealed that women who had lower activity in food reward regions of the brain and who had genetic modifications associated with lower dopamine activity showed the greatest weight gain after one year. Eric Stice from the Oregon Research Institute says, "These findings provide some of the first prospective evidence that people who experience blunted reward from food may compensate by overeating, increasing risk for unhealthy weight gain." Overconsumption of appetizing foods may occur in an attempt to increase brain reward in less responsive systems. The results of this study highlight the need for further research into the role that neural reward systems play in the development of obesity. "It may be useful for individuals who show low food-related reward to increase their physical activity, which not only promotes activity the same reward circuitry but also reduces unhealthy weight gain from overeating" says Stice.
Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), July 28 - August 1, 2009, the foremost society for research into all aspects of eating and drinking behavior, finds that after a 6-month behavioral weight loss program, depressed patients not only lost 8% of their initial weight but also reported significant improvements in their symptoms of depression, as well as reductions in triglycerides, which are a risk factor for heart disease and stroke. The results of this study highlight the need for further research into the effects of weight loss in individuals suffering from psychiatric disorders.
Health and population trends could increase demand for cardiothoracic surgeons in the United States far greater than the supply - diminishing and delaying care, according to a report in Circulation: Journal of the American Heart Association.
Traditional hospital factors-such as case volume and academic status-do not appear to predict whether patients with cardiac arrest at that facility are likely to experience delays in receiving defibrillation, according to a report in the July 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
People who are rewarded for making correct decisions learn quickly. While
Calypso Medical Technologies, Inc., announced the publication of data from a clinician sponsored investigational study conducted at the University of Pennsylvania, demonstrating the utility of the Calypso® System in tracking tumor movement in the pancreas. The data will be presented at the 51st Annual Meeting of the American Association of Physicists in Medicine (AAPM), July 26-30, at the Anaheim Convention Center. "In areas of the body, such as the pancreas, that are susceptible to respiratory motion it can prove difficult to handle the spectrum of motion that can arise," said James Metz, M.D., Clinical Director, Department of Radiation Oncology, The University of Pennsylvania Health System.
Schistosomiasis, one of the most important of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus Schistosoma. These parasites are long lived (>10 years) and dwell within blood vessels, where they produce eggs that become the focus of intense, chronic inflammatory responses. In severe cases, this inflammation is associated with life-threatening liver disease.
Engineers at the University of Leeds (UK) are developing a way to capture the kinetic energy produced when soldiers march and use it to power their equipment.
Couples struggling with fertility problems have a new option for assessing their ability to have a child with the start-up of a new Buffalo-based company called LifeCell Dx, Inc. (LCDX).
A new proposal from the Centers for Medicare and Medicaid Services (CMS) to cut payments for radiation therapy treatments would cause many cancer centers to close, stop accepting Medicare patients, lay off support staff and reduce services to cancer patients, according to a survey conducted by ASTRO, the American Society for Radiation Oncology.
Eight million Americans are covered by Health Savings Account (HSA)-eligible insurance plans, an increase of more than 31 percent since last year, a new census released today by America"s Health Insurance Plans (AHIP) finds. Health Savings Accounts were authorized starting in January 2004. Since then, AHIP has conducted a periodic census of its members participating in the HSA/high-deductible health plan (HDHP) market.
The International Diabetes Federation African Region (IDF Africa) launched a critical action plan today to address the escalating threat that diabetes poses to the region. The plan identifies three key areas of action: government, primary healthcare and the community, defining a clear step-based strategy for tackling diabetes and implementing the UN Resolution on diabetes in Africa. IDF Africa is now calling for immediate adoption and implementation of the action plan, to tackle a disease which if not addressed soon has potential to threaten the viability of many African economies.1
Expanded results of a study conducted on children with eye cancer (retinoblastoma) shows that chemotherapy delivered through endovascular (through the vessel) means not only successfully cures the cancer in a majority of cases, but achieves this cure with preserved vision. Study outcomes were presented this week at the Society of NeuroInterventional Surgery (SNIS) 6th Annual Meeting in Boca Raton, FL by lead author Pierre Gobin, Professor of Radiology in Neurosurgery and Neurology at the Weill Cornell Medical Center at New York Presbyterian Hospital in New York City.
RadMD LLC has become the first company to offer a broad range of accredited CME courses in the area of medical imaging for pharmaceutical, medical device and biotech clinical trials.